A bipolar personality of yeast prion proteins

Yeast Prions: Proteins Templating Conformation and an Anti-prion System

Most yeast prions (infectious proteins) are amyloids, linear β-sheet-rich polymers of a single protein with the β-strands perpendicular to the long axis of the filament. A single prion protein can form any of many different prion variants, differing in structure and biological properties, but with the same amino acid sequence. The folded in-register parallel β-sheet architecture we have shown f...

Mechanism of Cross-Species Prion Transmission An Infectious Conformation Compatible withTwo Highly Divergent Yeast Prion Proteins

Efficiency of interspecies prion transmission decreases as the primary structures of the infectious proteins diverge. Yet, a single prion protein can misfold into multiple infectious conformations, and such differences in "strain conformation" also alter infection specificity. Here, we explored the relationship between prion strains and species barriers by creating distinct synthetic prion form...

Assembly of the yeast prion

Personality Dimensions of Temperament and Character in Patients with Borderline Personality Disorder and Bipolar Disorder II

Introduction: The purpose of this study was to investigate and compare personality dimensions of temperament and character in patients with borderline personality and bipolar II disorders in order to evaluate the hypothesis of “belonging of borderline personality disorder in moods disturbance spectrum.” Materials and Methods: 43 patients with borderline personality disorder, 47 patients with bi...

A Prion in yeast Huntington's disease

Huntingtin-like proteins make yeast sick (bottom). eriin et al., reporting on page 997, have developed the first yeast model for studying Huntington's disease. Yeast cannot undergo neurodegeneration, of course, but the simplicity and genetic manipulability of the system are already providing important mechanistic insights. The authors report that aggregation of a polypeptide with an expanded po...